11/9/2023 0 Comments Side effect of xeljanzFour cases of Xeljanz pulmonary embolism turned up in ulcerative colitis patients taking the 10 mg twice daily dose. Xeljanz is part of the JAK inhibitor drug class, which interferes with an enzyme that plays a critical role in immune cell signaling. When a blood clot breaks off and travels to the lungs, it is called a pulmonary embolism. Though not well-studied, these same risks apply to patients using the drug to treat ulcerative colitis. Preliminary results from an ongoing clinical trial revealed 19 cases of blood clots in the lungs of these patients compared to just three cases in patients using TNF blockers to treat their Rheumatoid Arthritis. According to the FDA’s most serious warning, the higher (10 mg, twice daily) increases the risk of blood clots and death. Food and Drug Administration added a new black box warning to the product label. The connection between this drug and blood clots became clear in July 2019 when the U.S. Patients and their families affected by severe Xeljanz side effects may contact our Virginia-based law firm Rutter Mills to inquire about filing a Xeljanz lawsuit. Xeljanz has always carried black box warnings for the risk of malignant infections, lymphoma, and Epstein-Barr but offered no alerts related to cardiovascular effects. While some side effects can be reasonably expected– sudden life-threatening events and deaths without sufficient warning are unacceptable. These side effects are listed on the warning label and often clear up within one to two weeks. Clinical exams reveal increased blood creatine phosphokinase and elevated cholesterol levels. In addition, headaches, rashes, and anemia have also been reported. This medication can also be tough on the digestive tract, causing diarrhea, nausea, and gastroenteritis. Since it lowers immune system activity, users may contract Nasopharyngitis viral infections, upper respiratory infections, and shingles. The most common Xeljanz side effects are relatively mild.
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